Lasmiditan Succinate CAS 439239-92-6

Produk Penerangan:

Product Name: Lasmiditan Succinate CAS 439239-92-6

 

Sinonim:

2,4,6-trifluoro-N-{6-[(1-methylpiperidine-4-yl)carbonyl]pyridin-2-yl}benzamide hemisuccinate;

 

Kimia & Fizikal Hartanah

Rupa: Off-white powder

Assay: NLT99%

Air kelarutan: Air: 14 mg/mL (16.04 mM)

Kelarutan: DMSO: 100 mg/mL (114.57 mM);Ethanol: 9 mg/mL (10.31 mM)

 

Application:2,4,6-trifluoro-N-{6-[(1-methylpiperidine-4-yl)carbonyl]pyridin-2-yl}benzamide is a novel 5-}HT(1F) receptor agonist acting on the central nervous system with a Ki value of 2.21 nM and no vasoconstrictive activity.

 

Lasmiditan, also known as COL-144 and LY573144, is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1=2.21 μM) without vasoconstrictor activity that seemed effective when given as an intravenous infusion in a proof-of-concept migraine study. Lasmiditan showed efficacy in its primary endpoint, with a 2-hour placebo-subtracted headache response of 28.8%, though with frequent reports of dizziness, paresthesias, and vertigo.

 

 

 

 

Produk under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.

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